Loargys mode of action1
Loargys is a novel, pegylated, cobalt-substituted recombinant human arginase 1 enzyme.
Loargys has been engineered to deliver enhanced degradation of arginine.1,2
Compared with the native enzyme, Loargys achieves higher catalytic activity and longer half-life.1,2
Loargys acts by reducing plasma levels of arginine, with corresponding increases in plasma ornithine levels and decreases in plasma guanidino compound levels.3
- Stone EM, et al. Replacing Mn2+ with Co2+ in Human Arginase I Enhances Cytotoxicity Towards L-Arginine Auxotrophic Cancer Cell Lines. ACS Chem Biol. 2010;5:333–342.
- Stone EM, et al. Strategies for Optimizng the Serum Persistence of Engineered Human Arginase I for Cancer Therapy. J Control Release. 2012;158:171–179.
- Loargys Summary of Product Characteristics (Nov 2025).